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Hazards of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant use of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may bring about an increase in tramadol plasma stages along with a lower in the amounts of the Energetic metabolite, M1.Healthdirect Australia jus